Role of Mast Cells in Pityriasis Lichenoides Chronica and Mycosis Fungoides
Journal of Pan-Arab League of Dermatologists
Vol. 19, No. 2, June 2008 Page 9- 18
Role of Mast Cells in Pityriasis Lichenoides Chronica and MycosisFungoides
Hanan Nada & Solafa Al-Abyad
Departments of Dermatology & Pathology, Faculty of Medicine, Cairo University, Egypt
Abstract
Background: Pityriasis Lichenoides Chronica(PLC) and Mycosis Fungoides (MF) are T-celllymphoproliferative disorder that presents aspersistent scaly erythematous lesion over thebody.
Aim: This study was conducted to evaluate mastcell content and distribution in both PLC andMF.
Method: Eighteen cases of PLC and MF weresubjected to histopathological and immunohistochemicalstudy.
Result: Mast cell count was found to be increasedin PLC and MF lesions if compared tonormal skin. Also, PLC and MF lesions characterizedby hyperpigmentation, lichenificationand itching showed increased number of mastcells and they distributed mainly close to dermaoepidermaljunction if compared to erythematouslesions of PLC and MF.
Conclusion: PLC lesion showed elevated meanmast cell count in the upper dermis. Furtherstudy needed to evaluate the role of mast cellsand their mediators in case of PLC and MF.
Journal of Pan-Arab League of Dermatologists
Vol. 19, No. 2, June 2008 Page 9- 18
Role of Mast Cells in Pityriasis Lichenoides Chronica and MycosisFungoides
Hanan Nada & Solafa Al-Abyad
Departments of Dermatology & Pathology, Faculty of Medicine, Cairo University, Egypt
Abstract
Background: Pityriasis Lichenoides Chronica(PLC) and Mycosis Fungoides (MF) are T-celllymphoproliferative disorder that presents aspersistent scaly erythematous lesion over thebody.
Aim: This study was conducted to evaluate mastcell content and distribution in both PLC andMF.
Method: Eighteen cases of PLC and MF weresubjected to histopathological and immunohistochemicalstudy.
Result: Mast cell count was found to be increasedin PLC and MF lesions if compared tonormal skin. Also, PLC and MF lesions characterizedby hyperpigmentation, lichenificationand itching showed increased number of mastcells and they distributed mainly close to dermaoepidermaljunction if compared to erythematouslesions of PLC and MF.
Conclusion: PLC lesion showed elevated meanmast cell count in the upper dermis. Furtherstudy needed to evaluate the role of mast cellsand their mediators in case of PLC and MF.