Expression of CD10, CD30, CD56 and CD68 in Some Variants of Peripheral T-cell Lymphoma: An Immunohis
Journal of Pan-Arab League of Dermatologists
Vol. 18, No. 2, June 2007 Page 75- 90
Expression of CD10, CD30, CD56 and CD68 in Some Variants of Peripheral T-cell Lymphoma: An Immunohistochemical Study
Amal El-Ashmawy, Arwa Hassan, Amany Abdel-Latif, Zeinab Abd El-Samad, Omnia Rizk*
Departments of Dermatology and Venereology and Pathology*, Faculty of Medicine, Tanta University
Abstract
Peripheral T-cell lymphomas (PTCLs) are a group of non-Hodgkin’s lymphomas sharing a derivation from neoplastic T-cells. Angioimmunoblastic T-cell lymphoma (AITCL), subcutaneous panniculitis like T-cell lymphoma (SPTCL) and cutaneous anaplastic large cell lymphoma (CALCL) are among PTCL variants having cutaneous manifestations. We aimed to verify the utility of CD10, CD30, CD56 and CD68 immunohistochemical expression in the diagnosis of AITCL, SPTCL and CALCL. Fifteen patients with PTCLs including 5 AITCL, 5 SPTCL and 5 CALCL cases were included in the study. Involved skin and lymph node biopsy specimens were studied immunohistochemically for the expression of CD10, CD30, CD56 and CD68. In AITCL, CD10 was expressed in lymph node in all cases and in the skin of one case. CD68 was expressed in all SPTCL cases and in none of AITCL or CALCL. Four cases of CALCL were CD30+ while one CALCL, all AITCL and SPTCL cases were CD30-negative. CD56 was expressed only in 3 cases of SPTCL (γ/δ TCL) and one case of CALCL. Coexpression of CD30 and CD56 was detected in one case of CALCL. In conclusion, among the 3 studied types of PTCL, CD10 (in lymph nodes) is a sensitive and specific marker for AITCL. CD68 is a sensitive and specific marker for SPTCL. CD30 was sensitive and specific for CALCL. However, one case of CD30-negative CALCL was detected. CD56 can help to differentiate between the two pathologic types of SPTCL, α/β and γ/δ TCL. They are important to distinguish for biologic, therapeutic and prognostic reasons. In addition, although coexpression of CD30 and CD56 in CALCL is a rare finding, it might identify a subset of CD30+ lymphomas with more aggressive features.
Journal of Pan-Arab League of Dermatologists
Vol. 18, No. 2, June 2007 Page 75- 90
Expression of CD10, CD30, CD56 and CD68 in Some Variants of Peripheral T-cell Lymphoma: An Immunohistochemical Study
Amal El-Ashmawy, Arwa Hassan, Amany Abdel-Latif, Zeinab Abd El-Samad, Omnia Rizk*
Departments of Dermatology and Venereology and Pathology*, Faculty of Medicine, Tanta University
Abstract
Peripheral T-cell lymphomas (PTCLs) are a group of non-Hodgkin’s lymphomas sharing a derivation from neoplastic T-cells. Angioimmunoblastic T-cell lymphoma (AITCL), subcutaneous panniculitis like T-cell lymphoma (SPTCL) and cutaneous anaplastic large cell lymphoma (CALCL) are among PTCL variants having cutaneous manifestations. We aimed to verify the utility of CD10, CD30, CD56 and CD68 immunohistochemical expression in the diagnosis of AITCL, SPTCL and CALCL. Fifteen patients with PTCLs including 5 AITCL, 5 SPTCL and 5 CALCL cases were included in the study. Involved skin and lymph node biopsy specimens were studied immunohistochemically for the expression of CD10, CD30, CD56 and CD68. In AITCL, CD10 was expressed in lymph node in all cases and in the skin of one case. CD68 was expressed in all SPTCL cases and in none of AITCL or CALCL. Four cases of CALCL were CD30+ while one CALCL, all AITCL and SPTCL cases were CD30-negative. CD56 was expressed only in 3 cases of SPTCL (γ/δ TCL) and one case of CALCL. Coexpression of CD30 and CD56 was detected in one case of CALCL. In conclusion, among the 3 studied types of PTCL, CD10 (in lymph nodes) is a sensitive and specific marker for AITCL. CD68 is a sensitive and specific marker for SPTCL. CD30 was sensitive and specific for CALCL. However, one case of CD30-negative CALCL was detected. CD56 can help to differentiate between the two pathologic types of SPTCL, α/β and γ/δ TCL. They are important to distinguish for biologic, therapeutic and prognostic reasons. In addition, although coexpression of CD30 and CD56 in CALCL is a rare finding, it might identify a subset of CD30+ lymphomas with more aggressive features.