Taq I & Apa I Restriction Fragment Length Polymorphism for the Study of Vitamin D Receptor Gene Poly
Abstract
Background: Analogues of vitamin D were found to be effective in treatment of skin lesions of psoriasis through its receptor by correcting the proliferation differentiation balance. Adding to this, its effect on T helper cells which has a big role in pathogenesis of psoriasis. There is a debate about the association of vitamin D receptor gene polymorphism with psoriasis in different populations.
Patients and methods: Fifty psoriasis patients were examined using the restriction fragment length polymorphism for studying of Apa I and Taq I genotypes of vitamin D receptors in a sample of Egyptian patients comparing them to 20 healthy control subjects.
Results: Our study showed absence of significant difference in vitamin D receptor polymorphism between patients and controls.
Conclusion: Vitamin D receptor gene polymorphism has an ethnic variation and association with other functionally known gene polymorphism not itself alone might be responsible for the pathogenesis of psoriasis.
Received: 19 February 2009
Accepted: 1st referee: 7 March 2009
2nd referee: 2 April 2009
Taq I & Apa I Restriction Fragment Length Polymorphism for the Study of Vitamin D Receptor Gene Polymorphism in Egyptian Psoriatic Patients
Mostafa Mokhtar Kamel*, Nehal Mohammed Zu El-Fakkar*, Marwa Kamal Asaad*, Manal Zaghlool Younis** and Abeer El-Sayed Aly Shehab**
Departments of Dermatology* and Clinical Pathology**, Faculty of Medicine, Ain Shams University
Abstract
Background: Analogues of vitamin D were found to be effective in treatment of skin lesions of psoriasis through its receptor by correcting the proliferation differentiation balance. Adding to this, its effect on T helper cells which has a big role in pathogenesis of psoriasis. There is a debate about the association of vitamin D receptor gene polymorphism with psoriasis in different populations.
Patients and methods: Fifty psoriasis patients were examined using the restriction fragment length polymorphism for studying of Apa I and Taq I genotypes of vitamin D receptors in a sample of Egyptian patients comparing them to 20 healthy control subjects.
Results: Our study showed absence of significant difference in vitamin D receptor polymorphism between patients and controls.
Conclusion: Vitamin D receptor gene polymorphism has an ethnic variation and association with other functionally known gene polymorphism not itself alone might be responsible for the pathogenesis of psoriasis.