Primary Cutaneous Follicle Center LymphomaDiffuse Large B cell Variant

Cutaneous follicular lymphoma is the most common type of primary B-cell lymphoma of the skin. Based on architectural features, it could be classified as follicular, follicular &diffuse and minimally follicular. Rarely, exclusively diffuse follicular pattern may be seen

(!). Our case was a 40-year-old male had grouped, glistening, firm, reddish nodules on the scalp of about a year. No lymph node affection was detected either clinically or by CT scanning. Lesional Skin biopsy revealed diffuse dense atypical large B-cell lymphocytic infiltrate occupying the whole dermis with marked nuclear pleomorphism. In addition, diffusely coalescent follicles were noticed. The specimen was moderately positive for bcl-2 stain. The clinicopathologic features were those of primary cutaneous B cell lymphoma. The patient prescribed herein had a unique presentation of diffuse large B lymphoma as a variant of primary cutaneous folliclecenter lymphoma

Cutaneous follicular lymphoma is the most common type of primary B-cell lymphoma of the skin. Based on architectural features, it could be classified as follicular, follicular &diffuse and minimally follicular. Rarely, exclusively diffuse follicular pattern may be seen (!). Our case was a 40-year-old male had grouped, glistening, firm, reddish nodules on the scalp of about a year. No lymph node affection was detected either clinically or by CT scanning. Lesional Skin biopsy revealed diffuse dense atypical large B-cell lymphocytic infiltrate occupying the whole dermis with marked nuclear pleomorphism. In addition, diffusely coalescent follicles were noticed. The specimen was moderately positive for bcl-2 stain. The clinicopathologic features were those of primary cutaneous B cell lymphoma. The patient prescribed herein had a unique presentation of diffuse large B lymphoma as a variant of primary cutaneous folliclecenter lymphoma