Evaluation of IL2 and IFN γ mRNA Gene Expression in Resistant Genital and Plantar Warts, Treated by
Journal of Pan-Arab League of Dermatologists
Vol. 20, No. 1, February 2009 Page 147- 158
Evaluation of IL2 and IFN γ mRNA Gene Expression in Resistant Genitaland Plantar Warts, Treated by Intralesional Tuberculin
Sahar S Youssef*, Heba Diab*, Mohamed A Naeem Sallam* and Alaa Ahmed**
Departments of Dermatology, Andrology & Venereology* and Bacteriology & Immunology**, Faculty of Medicine,
Ain Shams University
Abstract
Background: Intralesional immunotherapy withskin test antigens was found to be effective intreating patients with multiplegenital andextragenital warts.
Objective: To probe into the immunological mechanismsand clinical therapeutic effect of usingtuberculin immunotherapy as a treatment modalityfor genital and plantar warts.
Methods: Eight patients with genital warts and10 patients with plantar warts were included inthis open-label pilot study. PPD-Tuberculin wasinjected intralesionally onbiweekly sessions.Wart biopsies were taken at pre-study and atweek 6 to measure IL2 and IFNγ mRNA geneexpression.
Results: Treatment with intralesional tuberculinwas associated with statistically significant increasein local wart level of IL2 andIFNγmRNA in responding warts compared to nonresponding warts (p=0.001). Complete wart regressionwas achieved in100% and 63.6% ofgenital and plantar warts, after 3.29±0.76 and5.0±36.33 sessions respectively. Total wart regressionwas maintained over a six months follow-up period.
Conclusion: The present study demonstratesthat tuberculinimmunotherapy is an effectiveand safe modality for treatment of genital andnon genital warts through stimulation of IL2andIFNγ cytokines suggesting activation of acell mediated immune response .This ensurescontrol of infection and long termprotectionagainst recurrence..
Journal of Pan-Arab League of Dermatologists
Vol. 20, No. 1, February 2009 Page 147- 158
Evaluation of IL2 and IFN γ mRNA Gene Expression in Resistant Genitaland Plantar Warts, Treated by Intralesional Tuberculin
Sahar S Youssef*, Heba Diab*, Mohamed A Naeem Sallam* and Alaa Ahmed**
Departments of Dermatology, Andrology & Venereology* and Bacteriology & Immunology**, Faculty of Medicine,
Ain Shams University
Abstract
Background: Intralesional immunotherapy withskin test antigens was found to be effective intreating patients with multiplegenital andextragenital warts.
Objective: To probe into the immunological mechanismsand clinical therapeutic effect of usingtuberculin immunotherapy as a treatment modalityfor genital and plantar warts.
Methods: Eight patients with genital warts and10 patients with plantar warts were included inthis open-label pilot study. PPD-Tuberculin wasinjected intralesionally onbiweekly sessions.Wart biopsies were taken at pre-study and atweek 6 to measure IL2 and IFNγ mRNA geneexpression.
Results: Treatment with intralesional tuberculinwas associated with statistically significant increasein local wart level of IL2 andIFNγmRNA in responding warts compared to nonresponding warts (p=0.001). Complete wart regressionwas achieved in100% and 63.6% ofgenital and plantar warts, after 3.29±0.76 and5.0±36.33 sessions respectively. Total wart regressionwas maintained over a six months follow-up period.
Conclusion: The present study demonstratesthat tuberculinimmunotherapy is an effectiveand safe modality for treatment of genital andnon genital warts through stimulation of IL2andIFNγ cytokines suggesting activation of acell mediated immune response .This ensurescontrol of infection and long termprotectionagainst recurrence..