Mesotherapy using Dutasteride-Containing Solution in Male Pattern Hair Loss: a Controlled Pilot Stud

Journal of Pan-Arab League of Dermatologists
Vol. 20, No. 1, February 2009  Page 137- 145

Mesotherapy using Dutasteride-Containing Solution in Male Pattern HairLoss: a Controlled Pilot Study
Marwa Abdallah*; Khaled El-Zawahry* and Hanan Besar**
Departments of Dermatology and Venereology*, Faculty of Medicine, Ain Shams University and Tahreer General
Hospital**, Cairo, Egypt

Abstract
 
Background: Controlled studies on the value of mesotherapy in the treatment of male pattern hair loss (MPHL) are lacking. Aim: To evaluate the efficacy and safety of intradermal injection of 0.05% dutasteridecontaining solution in comparison to 0.9% saline injected via nappage technique.

Patients & Methods: Twenty eight male patients with MPHL types III, IV and V completed the study. They were randomly assigned to two groups: group I the treated group (n=14) and group II controls (n=14). Patients received seven injections at weeks 0,1,2,3, 5, 7 and 11 and were evaluated at week 12.

Results: The dutasteride-containing preparation was significantly more effective (p<0.05) than placebo. This was evident by three assessment methods; difference in hair count, professional independent observers’ assessment and patients’ self assessment. The less the duration of MPHL, the better was the response to mesotherapy. Minimal side effects in the form of mild pain and headache were detected.

Conclusion: Mesotherapy using dutasteridecontaining solution is an effective method in treating moderate degrees of MPHL, further studies using dutasteride alone and for longer periods are recommended.

Journal of Pan-Arab League of Dermatologists
Vol. 20, No. 1, February 2009  Page 137- 145

Mesotherapy using Dutasteride-Containing Solution in Male Pattern HairLoss: a Controlled Pilot Study
Marwa Abdallah*; Khaled El-Zawahry* and Hanan Besar**
Departments of Dermatology and Venereology*, Faculty of Medicine, Ain Shams University and Tahreer General
Hospital**, Cairo, Egypt

Abstract
 
Background: Controlled studies on the value of mesotherapy in the treatment of male pattern hair loss (MPHL) are lacking. Aim: To evaluate the efficacy and safety of intradermal injection of 0.05% dutasteridecontaining solution in comparison to 0.9% saline injected via nappage technique.

Patients & Methods: Twenty eight male patients with MPHL types III, IV and V completed the study. They were randomly assigned to two groups: group I the treated group (n=14) and group II controls (n=14). Patients received seven injections at weeks 0,1,2,3, 5, 7 and 11 and were evaluated at week 12.

Results: The dutasteride-containing preparation was significantly more effective (p<0.05) than placebo. This was evident by three assessment methods; difference in hair count, professional independent observers’ assessment and patients’ self assessment. The less the duration of MPHL, the better was the response to mesotherapy. Minimal side effects in the form of mild pain and headache were detected.

Conclusion: Mesotherapy using dutasteridecontaining solution is an effective method in treating moderate degrees of MPHL, further studies using dutasteride alone and for longer periods are recommended.

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