Familial Lichen Planus
Journal of Pan-Arab League of Dermatologists
Vol. 20, No. 1, February 2009 Page 97- 104
Familial Lichen Planus
Hamza Abdel-Raouf
Department of Dermatology, STD’s & Andrology, Al-Minya University, Al-Minya, Egypt
Abstract
Background: Familial Lichen Planus (FLP) isa rare condition. The clinical picture of this diseaseamong Egyptian people hasnot been described.
Objective: to report a series of patients withFLP and to describe the clinical characteristicsof this varietyof lichen planus (LP)
Methods: In this study, affected individuals withLP who presented to the Dermatology DepartmentofAl-Minya University Hospital wereasked about the occurrence of similar skin diseasein other family members. The followingparameterswere analyzed in cases diagnosed asFLP: age of onset, gender predilection, lesionaldistribution, nail and mucosalinvolvement,clinical course, and inheritance pattern.
Results: Twenty-one individuals in nine familieswere affected. Males weremore commonly affectedthan females (57% vs 43%). Actinic LPwas the commonest among males and melasmalikeLP wasthe commonest among females. Nailinvolvement occurred in 9 patients (43%) andthe disease was confined to nails in 4 of the21diagnosed cases (I9%). Four patients showedmucosal involvement (19%). Only two patientsshowed lesion of lichenplanopilaris. The diseasefollowed a chronic fluctuating course withfrequent relapses often occurred after partialremission.
Conclusion: Familial cases of lichen planus arepresent among people in Upper Egypt. It seemsthat cases are not looked forand so the entity isunder-estimated.
Journal of Pan-Arab League of Dermatologists
Vol. 20, No. 1, February 2009 Page 97- 104
Familial Lichen Planus
Hamza Abdel-Raouf
Department of Dermatology, STD’s & Andrology, Al-Minya University, Al-Minya, Egypt
Abstract
Background: Familial Lichen Planus (FLP) isa rare condition. The clinical picture of this diseaseamong Egyptian people hasnot been described.
Objective: to report a series of patients withFLP and to describe the clinical characteristicsof this varietyof lichen planus (LP)
Methods: In this study, affected individuals withLP who presented to the Dermatology DepartmentofAl-Minya University Hospital wereasked about the occurrence of similar skin diseasein other family members. The followingparameterswere analyzed in cases diagnosed asFLP: age of onset, gender predilection, lesionaldistribution, nail and mucosalinvolvement,clinical course, and inheritance pattern.
Results: Twenty-one individuals in nine familieswere affected. Males weremore commonly affectedthan females (57% vs 43%). Actinic LPwas the commonest among males and melasmalikeLP wasthe commonest among females. Nailinvolvement occurred in 9 patients (43%) andthe disease was confined to nails in 4 of the21diagnosed cases (I9%). Four patients showedmucosal involvement (19%). Only two patientsshowed lesion of lichenplanopilaris. The diseasefollowed a chronic fluctuating course withfrequent relapses often occurred after partialremission.
Conclusion: Familial cases of lichen planus arepresent among people in Upper Egypt. It seemsthat cases are not looked forand so the entity isunder-estimated.