Expression of Fractalkine (CX3CL1) in Patients with Psoriasis and AtopicDermatitis
Journal of Pan-Arab League of Dermatologists
Vol. 19, No. 3, October 2008 Page 61- 68
Expression of Fractalkine (CX3CL1) in Patients with Psoriasis and Atopic
Dermatitis
Omar Azzam*, Tahra Leheta*, Rania Abdel Hay*, Marwa Fawzy*, Amira El Tawdy* and Laila Rashed**
Departments of Dermatology* & Biochemistry**, Faculty of Medicine, Cairo University
Abstract
Background:Fractalkine (FKN) is a unique,membrane-bound chemokine, which exists intotwo forms; the soluble form is a potent chemotacticagent for T cellsand the anchored formfunctions as an adhesion molecule
Objective: Psoriasis and atopic dermatitis (AD)lesions were examined to gain insight into theexpression of FKN in pathologic lesions characterizedby aprevalent Th1 or Th2 response.
Methods: This study included 20 psoriatic patients(group 1), 20 AD patients (group 2) andten healthy individuals serving as controls(group 3). Skin biopsy wastaken from both patientsgroups and volunteers for detection ofFKN level by ELISA.
Results: Fractalkine was detected in all psoriaticpatients with a mean of 204.385 μg/mg tissue,and in atopic patients with a mean of229.225 μg/mg tissue.Regarding to the healthyindividuals (group 3); FKN was detected with amean of 219.150 μg/mg tissue. Statistical analysisrevealed a significant difference (P value0.047) between the three studied groups.
Conclusions: FKN can play a role in the recruitmentof lymphocytes during the inflammatoryreaction in atopic dermatitis and in psoriasis.
Journal of Pan-Arab League of Dermatologists
Vol. 19, No. 3, October 2008 Page 61- 68
Expression of Fractalkine (CX3CL1) in Patients with Psoriasis and Atopic
Dermatitis
Omar Azzam*, Tahra Leheta*, Rania Abdel Hay*, Marwa Fawzy*, Amira El Tawdy* and Laila Rashed**
Departments of Dermatology* & Biochemistry**, Faculty of Medicine, Cairo University
Abstract
Background:Fractalkine (FKN) is a unique,membrane-bound chemokine, which exists intotwo forms; the soluble form is a potent chemotacticagent for T cellsand the anchored formfunctions as an adhesion molecule
Objective: Psoriasis and atopic dermatitis (AD)lesions were examined to gain insight into theexpression of FKN in pathologic lesions characterizedby aprevalent Th1 or Th2 response.
Methods: This study included 20 psoriatic patients(group 1), 20 AD patients (group 2) andten healthy individuals serving as controls(group 3). Skin biopsy wastaken from both patientsgroups and volunteers for detection ofFKN level by ELISA.
Results: Fractalkine was detected in all psoriaticpatients with a mean of 204.385 μg/mg tissue,and in atopic patients with a mean of229.225 μg/mg tissue.Regarding to the healthyindividuals (group 3); FKN was detected with amean of 219.150 μg/mg tissue. Statistical analysisrevealed a significant difference (P value0.047) between the three studied groups.
Conclusions: FKN can play a role in the recruitmentof lymphocytes during the inflammatoryreaction in atopic dermatitis and in psoriasis.