New Drug Treatments for Basal Cell Carcinoma
Alexander M. Castellino, PhD
Two studies published online May 13 in the Lancet Oncology provide data that impacts the clinical management of patients with advanced basal cell carcinoma (BCC).
One study, known as BOLT, profiles a new drug that is awaiting approval: sonidegib (Odomzo, Novartis). The manufacturer has filed for approval in Australia, the European Union, Switzerland, and the United States.
The other study, known as STEVIE, provides long-term safety data for vismodegib (Erivedge, Genentech), which was launched in 2012, from a setting representative of routine clinical practice.
Both drugs act as inhibitors of the Hedgehog signaling pathway.